Dear Aidan,
I don't think the value of the painting is a red herring. It is the subject of this topic, and I will come back to that in a moment.
The Spanish repatriation of gold & silver from the New World is a very different matter, worthy of its own topic. It is true that all that gold and silver ruined Spain, but it stimulated real wealth creation in other parts of the world. According to Felipe Fernandez-Armesto in his "Millennium; A History of the Last Thousand Years", half the silver bullion mined in South America ended up in the coffers of the Emperor of China, so it stimulated economic activity right across Eurasia. It also kick-started the development of England and its colonies through the activities of the Elizabethan licensed pirates, such as Drake and Raleigh, who stole from Spanish galleons and invested in more productive enterprises.
So, there might be an interesting parallel between the role of Spain in injecting liquidity into the global economy, and the USA today, which has injected vast amounts of liquidity in the form of dollars, which have kick-started the econonic revival of China and India, which were the two greatest centres of world economic power right up until about 1830. If this is so, it does not bode well for the future of the USA!
Meanwhile, back on topic, the da Vinci painting has value very different from that of the gold and silver plundered from South America. Gold and silver have intrinsic worth to just about anybody offered them in the form of coinage, but an oil painting's value lies in the fact of its uniqueness. The painting only shoots up in value because paintings by da Vinci are so rare.
The monetary value reflects the value system of a handful of wealthy individuals, looking for a home for their excess funds, and a small coterie of art experts, with some overlap between the two groups. We are supposed to believe that there is some sort of spiritual value in a great work of art, but exactly how this connects with its value in the art market is hard to understand.
Try the following thought experiment:
You may have heard recently that a new generation of laser printers has been developed which actually "print" three dimensional objects. So you can draw an object using Computer Aided Design software, then the printer will make the object. There is no technical reason why it should not become possible to scan a da Vinci painting and construct a perfect copy of it by assembling it from atoms and molecules. The cost of doing so for the first time would be massive, but then the cost of the technology would drop exponentially until we could all own such a device. So we could order a copy of the "Profile of the Bella Principessa" from Amazon and our printer would assemble it for us instantly.
So how much would the original painting be worth in such a world?